Note for Apollo Users: Apollo interfaces use DSP and memory resources for its internal mixer. The chart below will help you understand just how varied the DSP usage of each UAD plug-in can be - note that all values in the chart are taken at a 44.1kHz sample rate:
Working at a higher sample rate, such as 96kHz for example, will essentially cut the amount of UAD plug-ins you can use simultaneously in half or more. Most UAD plug-ins will use more DSP at higher sample rates (just as native plug-ins use more CPU at higher sample rates) so working at 44.1kHz will allow you to run the most instances of UAD plug-ins. How many UAD plug-ins you can run with any given UAD-2 device greatly depends on which plug ins you are using in particular and what sample rate you are working at.